Weight Loss Drug Cautions Ozempic and Wegovy

In today's fast-paced world, the desire for quick fixes and instant results can often lead people to look for shortcuts. One such area where this is increasingly evident is weight loss. The allure of shedding pounds rapidly has led many to explore prescription weight-loss drugs like Ozempic and Wegovy. However, while these medications have shown promise in helping individuals lose weight, it's crucial to understand their potential risks and limitations. This article aims to provide a comprehensive overview of Ozempic and Wegovy, their effectiveness, associated risks, and why a holistic approach to weight loss is always essential first.

Ozempic (semaglutide) and Wegovy (also semaglutide but at a higher dose) are medications primarily designed to manage type 2 diabetes by regulating blood sugar levels (1). They belong to a class of drugs known as GLP-1 receptor agonists, which mimic the hormone glucagon-like peptide-1 (2). This hormone helps regulate appetite and glucose metabolism (3).

When used for weight loss, these drugs work by (4):

• Suppressing Appetite: They slow down gastric emptying, making you feel fuller for longer, thereby reducing overall calorie intake.
• Regulating Blood Sugar: By stabilising blood sugar levels, they help reduce cravings and prevent overeating.
• Promoting Weight Loss: Clinical studies have shown that users of these drugs can experience significant weight loss when combined with diet and exercise. For example, a study published in the New England Journal of Medicine found that participants using semaglutide lost an average of 15% of their body weight over 68 weeks (5).

However, it's essential to note that while these drugs can aid in weight loss, they are not magic bullets. Sustainable weight loss requires a holistic approach that includes a healthy diet and regular physical activity. No medication can replace the benefits of a balanced lifestyle.

Like any medication, Ozempic and Wegovy come with their own set of risks and side effects. It's crucial to be aware of these before starting any weight loss regimen involving these drugs.

• Nausea and Vomiting: One of the most reported side effects, which can be quite severe for some users.
• Diarrhoea and Constipation: Gastrointestinal issues are common, affecting digestion and overall comfort.
• Abdominal Pain: Cramping and discomfort in the stomach area.

• Pancreatitis: Inflammation of the pancreas, which can be life-threatening if not treated promptly.
• Kidney Problems: These drugs can cause or exacerbate kidney issues, leading to potential renal failure.
• Gallbladder Issues: Increased risk of gallbladder disease, including gallstones.
• Thyroid Tumours: Laboratory studies on animals have shown an increased risk of thyroid C-cell tumours. While this has not been conclusively proven in humans, it remains a concern.

Ozempic and Wegovy may not be suitable for everyone. Certain individuals should avoid these medications due to the heightened risk of complications (7):

• People with a History of Pancreatitis: Given the risk of pancreatitis, those with a history of this condition should steer clear of these drugs.
• Individuals with Thyroid Cancer or Family History: Due to the potential risk of thyroid tumours, those with a personal or family history of thyroid cancer should avoid these medications.
• Pregnant or Breastfeeding Women: The safety of these drugs during pregnancy and breastfeeding has not been established, making them unsuitable for use during these periods.
• Severe Gastrointestinal Diseases: Those with severe gastrointestinal diseases should avoid these drugs as they can exacerbate symptoms.

It's imperative to consult a healthcare professional before starting any weight loss medication.

While the appeal of rapid weight loss through medication is undeniable, it's essential to remember that there are no true quick fixes. Sustainable weight loss requires a comprehensive approach that addresses diet, lifestyle, and overall well-being. This method not only helps you shed pounds but also ensures that you maintain your health and vitality over the long term.

Several studies show that diet and lifestyle changes create healthy weight-loss.

• Balanced Diet: Focus on a diet rich in whole foods, including fruits, vegetables, lean proteins, and whole grains. Avoid processed foods and sugary snacks, which can lead to weight gain and other health issues. Also, focus on The Glucose Goddess Method regarding the order of eating foods can be very powerful for weight loss. This, in short, involves eating vegetables and plants first, then proteins and fat, and lastly starches and sugars, including fruits. An example of this is to eat a salad first, then the meat and potatoes. This will help to keep blood sugar levels stable and will avoid spiking glucose and the hormone insulin, which creates weight gain. To read the science behind this way of eating, visit here. Incorporating a balanced variety of food groups ensures that your body gets all the necessary nutrients it needs to function optimally, including helping with weight loss.
• Portion Control: Be mindful of portion sizes to avoid overeating, even when consuming healthy foods. Utilising smaller plates can help manage portion sizes and prevent overindulgence. Listening to your body’s hunger cues and eating slowly can also contribute to better portion control.
• Hydration: Drink plenty of water throughout the day to support metabolism and overall health. Water is crucial for digestion, nutrient absorption, and maintaining energy levels. Aim for at least eight to twelve glasses of water per day, and consider increasing intake if you are physically active or live in a hot climate.

• Regular Exercise: Incorporate both aerobic and strength-training exercises into your routine. Aerobic exercises, like walking, running, or cycling, help optimise the functioning of your metabolism and improve cardiovascular health. Strength training, such as lifting weights or using resistance bands, builds muscle mass, which can boost your metabolism. Aim for at least 150 minutes of moderate-intensity exercise per week, and don't forget to include some form of physical activity every day.
• Sleep: Ensure you get adequate sleep, as poor sleep can negatively impact weight loss efforts. Lack of sleep can lead to hormonal imbalances that increase hunger and appetite, particularly for high-calorie foods (8). Aim for 7-9 hours per night and establish a consistent sleep routine to improve sleep quality.
• Stress Management: Practise stress-reducing techniques such as mindfulness, meditation, or yoga to support mental well-being. Chronic stress can lead to emotional eating and other behaviours that contribute to weight gain. Engaging in activities that promote relaxation and mental clarity can help manage your stress levels and support your weight loss journey.

By taking a holistic approach that combines these dietary changes and lifestyle modifications, you can achieve sustainable weight loss and improve your overall health. Remember, the goal is not just to lose weight but to cultivate a healthier, more balanced lifestyle that you can maintain for years to come.

Ozempic and Wegovy weight loss drugs have gained popularity as promising tools in the fight against obesity, offering significant weight loss benefits for some individuals. However, it's essential to approach these medications with caution and fully understand their potential risks. No doctor should prescribe these drugs without addressing diet and lifestyle first. Sustainable, long-term weight loss is best achieved through a balanced diet, regular exercise, and healthy lifestyle modifications.

Before considering drastic solutions such as weight loss drugs, consult with a healthcare professional to explore all available options. Remember, informed decision-making is key to achieving and maintaining a healthy weight, and always be sure to read the inserts provided with these drugs to understand the true list of potential side effects to weigh up the pros and cons of taking them.

For personalised advice and guidance on your weight loss journey, contact our team of healthcare professionals today, including qualified nutritional therapists. Nutritional therapists can help to create a diet and lifestyle plan that prioritises your health and well-being that is fully personalised to meet your unique needs.

Written by Amy Morris, BSc (Hons) Nutritional Therapy. Amy has been a nutritional therapist for 12 years, specialising in recent years as a functional medicine nutritional therapist. Women’s health, and pre-diabetes and type 2 diabetes prevention are Amy’s specialist areas. Diagnosed with a chronic condition called endometriosis at age 20, this is what motivated Amy to study nutrition. Amy has been in remission for 6 years now, attributing powerful nutrition, lifestyle and bio-identical hormone strategies she now shares with her clients. 

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